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KMID : 1189420120250010022
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Journal of Korean Oriental Medical Ophthalmology & Otolaryngology & Dermatology
2012 Volume.25 No. 1 p.22 ~ p.32
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The External Use Effects of Samwhangsejegami Extract on Atopic dermatitis of NC/Nga mice
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Hwang Choong-Yeon
Park Min-Cheol
Hong Seok-Hoon
Joo Hyun-A
Cho Hyun-Woo
Jung Soo-Young
Cho Jung-Hee
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Abstract
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Objectives: In this study, Samhwangsaejaegami extract was tested to prove its anti-atopic dermatitis effect on NC/Nga mice.
Methods: In order to evaluate the external use effects of Samhwangsaejae extract on anti-atopic dermatitis, the expression of filaggrin, serine palmitoyltransferase(SPT), and COX-2 were analyzed. In vivo study, clinical skin severity score, IgE, IL-4, IL-5 and IL-6 level were analyzed through NC/Nga atopic mice model after 12 weeks external treatment.
Results: In vitro study results showed the reduction in the expression of filaggrin, SPT, and COX-2. In vivo study results demonstrated the significant reduction in clinical skin severity score, IgE, IL-4, IL-5, IL-6 expression level.
Conclusions: These results showed Samhwangsaejaegami extract can be a promising candidate for anti-atopic dermatitis treatment.
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KEYWORD
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Samhwangsaejaegami extract(SHSJGE), filaggrin, serine palmitoyltransferase(SPT), COX-2, IgE
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